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. 2013 Feb 13;304(8):F1054–F1065. doi: 10.1152/ajprenal.00650.2012

Fig. 2.

Fig. 2.

Netrin-1 overexpression in proximal tubular epithelial cells suppresses IR-induced tubular atrophy and glomerular sclerosis. Top: periodic acid-Schiff (PAS)-stained section (2 left panels) and trichrome-stained section (right most panel) showing tubular and glomerular injury in WT and netrin-1 transgenic animals after sham surgery or IR. Scale bar = 100 μM. Bottom: quantification of tubular and glomerular injury in PAS-stained section as described in materials and methods. Netrin-1 overexpression suppressed both tubular and glomerular injury significantly. Values are means ± SE; n = 6. *P < 0.001 vs. sham. #P < 0.05 vs. WT IR.