Fig. 1.

Mean arterial pressure (MAP). A: male intact and gonadectomized control and intrauterine growth-restricted (IUGR) rats. B: female intact and gonadectomized control and IUGR rats. MAP was measured at 16 wk of age in chronically instrumented, conscious animals pretreated with enalapril (250 mg/l for 1 wk) at 3 time points: baseline, during acute angiotensin II (Ang II; 100 ng·kg⁻¹·min⁻¹), and during acute Ang II plus the Rho kinase antagonist fasudil (33 μg·kg⁻¹·min⁻¹). *P < 0.05 vs. control counterpart; †P < 0.05 vs. baseline counterpart; ‡P < 0.05 vs. intact counterpart; #P < 0.05 vs. Ang II counterpart. Values represent means ± SE.