Skip to main content
. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Trends Mol Med. 2011 Jul 29;17(11):650–658. doi: 10.1016/j.molmed.2011.06.008

Figure 3.

Figure 3

Regulation of angiogenesis by microRNAs (miRNAs). Multiple miRNAs regulate the angiogenic responses to growth factors or hypoxia. (a) Endothelial miRNAs that promote angiogenesis include miR-296, miR-132, miR-126, the miR-17-92 cluster, miR-130a and miR-210. By contrast, endothelial miRNAs that inhibit angiogenesis are miR-92a, miR-221 and miR-222. (b) The miR-17-92 cluster and miR-378 in tumor cells promote angiogenesis by repressing antiangiogenic factors. Suspected targets and regulators for each miRNAs are indicated. The vascular endothelial growth factor (VEGF) pathway can be regulated at multiple levels by miRNAs (a). miR-126 promotes VEGF signaling by repressing SPRED1, a negative regulator of the MAPK pathway, and by repressing PI3KR2, a negative regulator of the PI3K pathway. miR-132 represses the expression of p120RasGAP, which is a negative regulator of Ras and thereby induces neovascularization. miR-296 represses the expression of HGS, which regulates the intracellular sorting of activated VEGFR2 to lysosomes.