. Author manuscript; available in PMC: 2013 Apr 15.

Published in final edited form as: Trends Mol Med. 2011 Jul 29;17(11):650–658. doi: 10.1016/j.molmed.2011.06.008

Table 1.

Summary of microRNA involvement in angiogenesis

Stimulator	miRNA	Function	Targets^e	Refs.
VEGF^a	miR-132^b	Inhibition of miR-132 suppresses angiogenesis and decreases tumor burden in an orthotopic xenograft mouse model.	p120RasGAP	[56]
	miR-296^b	Increases the levels of proangiogenic growth factor receptors. Inhibition of miR296 reduces angiogenesis in tumor xenograft.	HGS	[53]
	miR-126^b	Regulates vascular integrity and angiogenesis.	PI3KR2, SPRED1	[48,51,52]
	miR-92a^c	Overexpression of miR-92a in EC blocks angiogenesis. Inhibition of miR-92a enhances angiogenesis and perfusion in limb ischemia and myocardial infarction.	Integrin a5	[54]
	miR-221/222^c	Reduce SCF^d-induced EC survival/migration/tube formation.	c-Kit	[49]
	miR-191, miR-155, miR-31, miR-17-5p, miR-18a, miR-20a	Expressed in VEGF time-dependent manner. Functions are not known.	Not known	[45]
Hypoxia	miR-210^b	Enhances EC survival/migration/tube formation.	Ephrin A3	[50]
Serum	miR-130a^b	Enhances EC migration/tube formation.	GAX, HOXA5	[47]

VEGF, vascular endothelial growth factor.

Indicates miRNAs that promote angiogenesis.

Indicates miRNAs that inhibit angiogenesis.

SCF, stem cell factor.

PI3KR2, phosphatidylinositol 3 kinase regulatory subunit 2; SPRED1, sprouty-related, EVH1 domain containing 1.