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Esophageal stromal cells secrete IL-6 in response to IL-1β. Primary cultures of esophageal stromal cells were treated with IL-1β (100, 5,000, and 10,000 U/ml) for 24 h (R&D), and IL-6 secretion was evaluated by ELISA. IL-6 secretion (142 pg/ml) was maximal in response to 5,000 U/ml IL-1β (*P < 0.05).
