Table 1.
TTGE analysis of cytochrome oxidase subunit III
| n | Fasting Glucose, mol/l | Total Errors in COX III | Average Errors per Animal | No. of Animals With Errors | |
|---|---|---|---|---|---|
| Wistar | 6 | 4.17 ± 0.11 | 0 | 0 | 0 |
| GK | 6 | 7.11 ± 0.44 | 13 | 2.2 | 4/6 |
| Wild type | |||||
| MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRY | |||||
| GMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMNQALLITILLG | |||||
| YFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG | |||||
| SYS | |||||
| Goto-Kakizaki: | |||||
| GK312 | |||||
| MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRY | |||||
| GMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMNQGPTNHHSL | |||||
| GK322 | |||||
| MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRY | |||||
| GMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRSHMSQALLITILLG | |||||
| LYFTILQASKMFRNIIFYL | |||||
| GK318 | |||||
| MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRY | |||||
| GMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMNQALLITILLG | |||||
| YFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRTTKIPLHIKTSFRIWSRSMMLTLR | |||||
| GK355 | |||||
| MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRY | |||||
| GMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMNQALLITILLG | |||||
| YFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRTLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWG | |||||
| SYS | |||||
GK, Goto-Kakizaki diabetic rat; TTGE, temporal temperature gradient analysis. Italicized and underlined sequences are the altered amino sequence resulting from the altered mtDNA sequence.