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Leucine-rich repeat-containing G-protein coupled receptor 5 is expressed by Ewing sarcomas. qRT-PCR analysis revealed low to very high-level expression of LGR5 in (A) 49 primary Ewing sarcoma (ES) and (B) 15 ES cell lines. For primary tumors levels of expression relative to GAPDH were <0.001% in 1 tumor, 0.001–0.01% in 7 tumors, 0.01–0.1% in 17 tumors, 0.1–1% in 12 tumors, 1–10% in 9 tumors, and 10–100% in 3 tumors.
