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. 2013 Apr 15;3:81. doi: 10.3389/fonc.2013.00081

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Copyright © 2013 Scannell, Pedersen, Mosher, Krook, Nicholls, Wilky, Loeb and Lawlor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Leucine-rich repeat-containing G-protein coupled receptor 5 is expressed by neural crest stem cells (NCSC). (A) qRT-PCR analysis of human embryonic stem cells (hESC), hESC-derived NCSC (hNCSC), hNCSC-derived mesenchymal stem cells (hNC-MSC), bone marrow-derived mesenchymal stem cells (hBM-MSC), and human lung embryo fibroblasts (MRC5) showed that undifferentiated hNCSC express the highest levels of LGR5. (B) Murine bone marrow stromal cells of neural crest origin express higher levels of Lgr5 than cells of mesodermal origin (from publically available microarray data GEO accession GSE30419) (Wislet-Gendebien et al., 2012). N = 3 ± SEM. Lines represent arithmetic means of replicate samples.