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. 2013 Apr 15;3:81. doi: 10.3389/fonc.2013.00081

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Copyright © 2013 Scannell, Pedersen, Mosher, Krook, Nicholls, Wilky, Loeb and Lawlor.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Exogenous Wnt3a induces nuclear localization of β-catenin and is potentiated by RSPO2. (A) CHLA25 cells grown in the presence of Wnt3a conditioned medium (CM) induced nuclear localization of β-catenin and this was robustly potentiated by the addition of RSPO2. RSPO2 alone had no effect on β-catenin nuclear localization. (B) The percentage of CHLA25, A673, and TC71 cells with nuclear β-catenin all increased with Wnt3a CM, but CHLA25 showed the greatest increase in nuclear localization with the addition of RSPO2. Data from three independent experiments and error bars are SEM.