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5-Aminoimidazole-4-carboxamide-3-ribonucleoside (AICAR) mitigates increase in blood pressure in reduced uterine perfusion pressure (RUPP) rats. The RUPP-induced increase in blood pressure was ameliorated with AICAR (50 mg/kg twice a day) treatment. *P < 0.05, different from NP; †P < 0.05, different from RUPP. Data presented as means ± SE; n = 8 RUPP, 8 normal pregnant (NP), 6 NP + AICAR (A), and 8 RUPP + A. MAP, mean arterial pressure.
