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AICAR administration increased placental tissue AMP-activated protein kinase (AMPK) phosphorylation in RUPP. The ratio of phosphorylated AMPK-α (pAMPK-α) to total AMPK-α was increased with AICAR (50 mg/kg twice a day) treatment in RUPP placenta (P < 0.05) compared with untreated RUPP animals. †P < 0.05, different from RUPP. Data presented as means ± SE; n = 8 RUPP, 8 NP, 6 NP + A, and 8 RUPP + A.
