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. 2013 Mar 12;3(3):e240. doi: 10.1038/tp.2013.16

Figure 2.

Figure 2

Maternal immune activation decreases social approach and social sniff. (a) No significant chamber preferences were found during the initial habituation period. (b) C57 offspring from saline and polyI:C-exposed dams showed significant preferences for the chamber with the novel mouse (*P<0.05), although the magnitude of preference was lower in the C57-polyI:C group. BTBR offspring from both saline and polyI:C-treated dams failed to show a preference for the chamber with the novel mouse. (c) Analysis of sociability scores showed that C57 offspring of polyI:C-treated dams were significantly less social than C57 mice from saline-treated dams (*P<0.05). Although BTBR mice from both saline and polyI:C treatment dams had reduced sociability scores compared with C57-saline controls (*P<0.05), no differences were observed between BTBR treatment groups. (d) C57 offspring of polyI:C-exposed dams showed less social sniff time than C57 offspring of saline-exposed C57 dams (*P<0.05). Both groups of BTBR offspring also showed less social sniff time than C57 offspring of saline-exposed C57 dams (*P<0.05). No significant differences were found in social sniff times between BTBR mice of either treatment condition.