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. 2013 Mar 12;3(3):e240. doi: 10.1038/tp.2013.16

Figure 5.

Figure 5

Dysregulated cytokine responses in offspring of polyI:C-treated dams. (a) IL-6 levels were significantly higher in BTBR than C57 offspring (*P<0.05). (b) IL-17 levels were significantly elevated in BTBR offspring versus C57 mice (*P<0.05) and levels were higher in BTBR-polyI:C offspring than BTBR-saline offspring (**P<0.05). (c) BTBR mice expressed greater concentrations of IL-10 compared with C57 mice and increased levels of IL-10 in BTBR offspring of polyI:C-treated dams compared with BTBR mice of saline-exposed dams approached significance (§P=0.05). (d) Both BTBR treatment groups expressed higher concentrations of TNFα compared with C57 mice with even greater increases observed in BTBR offspring of polyI:C-treated dams, though not statistically significance (§P=0.08).