Table 2.

Association between Childhood Neuropsychological Test Performance and Persistence of OCD Symptoms into Adulthood

	Adjusting for Gender, Age and OCD Severity at Childhood Neuropsychological Testing				Adjusting for Significant Childhood Comorbidities (ADHD and tic disorder)				Additionally Adjusting for Comorbidities and Primary Hoarding Symptoms
		95% CI				95% CI				95% CI
Test	HR	Lower	Upper	p	HR	Lower	Upper	p	HR	Lower	Upper	p
Fine-Motor Skill
Purdue Pegboard Dominant Hand	1.82	0.97	3.41	NS	3.78	1.30	11.02	0.015	3.94	1.28	12.15	0.017
Purdue Pegboard Non-dominant Hand	1.37	0.80	2.33	NS	1.39	0.79	2.44	NS	1.52	0.87	2.65	NS
Purdue Pegboard Bimanual	2.58	1.36	4.91	0.004	4.06	1.71	9.61	0.001	3.67	1.50	8.99	0.005
Visuospaital Skill
WISC-III Block Design Subscale*	1.25	0.89	1.77	NS	2.05	1.13	3.72	0.019	2.77	1.17	6.60	0.021
RCFT-Copy	0.87	0.47	1.59	NS	0.74	0.33	1.67	NS	0.42	0.11	1.59	NS
Nonverbal Memory
RCFT- Long-Term Recall	1.47	0.52	4.17	NS	1.10	0.38	3.17	NS	0.89	0.30	2.65	NS
Intelligence
WISC-III IQ	0.99	0.93	1.04	NS	1.05	0.98	1.13	NS	0.97	0.92	1.03	NS
Visual-Motor Integration
Beery Visual-Motor Integration Test	1.02	0.97	1.07	NS	1.01	0.96	1.06	NS	1.04	0.96	1.12	NS

This table presents a summary of the association between performance on childhood neuropsychological testing and the persistence of OCD Symptoms into adulthood. Neuropsychological tests in which significant associations were detected in exploratory analyses (p values < 0.05) are shaded in light gray and significant findings for a priori analyses (p values < 0.012) are shaded in dark gray. Hazard Ratios (HR) for each neuropsychological test are presented for Cox proportional hazard models with time to remission as the outcome measure and adjusting for covariates as indicated in the table. HR>1 indicate that poor performance is associated with greater persistence of symptoms into adulthood and HR<1 indicate that good performance is associated with persistence into adulthood.