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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Mol Psychiatry. 2011 Sep 20;17(12):1272–1282. doi: 10.1038/mp.2011.100

Figure 5. Forest Plot of Omega-3 Fatty Acids for Depression Stratified by Methodological Quality of Trials.

Figure 5

Omega-3 fatty acids tended to show greater efficacy in trials judged of lower quality (JADAD=3 or 4) than in trials judged of higher quality (JADAD=5 Test for subgroup differences: Chi2 = 7.2, df = 1 (P = 0.007), I2 = 86%). Clinical trials were stratified based on a median split of scores on the JADAD Scale The JADAD scale rates trials on presence and appropriateness of randomization and blinding as well as whether the number and reasons for dropouts was described in each trial.