Table 2.
Serum, cortical, and hippocampal (hippo) concentrations of E2, P4, and 3α, 5α-THP at test-time of OVX rats administered vehicle, E2 and/or P4, or 3α, 5α-THP subcutaneously
| Condition | Estrogen levels
|
Progesterone Levels
|
3α, 5α-THP levels
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Serum (pg/ml) | Cortex (ng/mg) | Hippo (ng/mg) | Serum (ng/ml) | Cortex (ng/g) | Hippo (ng/g) | Serum (ng/ml) | Cortex (ng/g) | Hippo (ng/g) | |
| OVX Vehicle SC | 0 | 0.1 ± 0.1 | 0 | 0.6 ± 0.6 | 1.2 ± 0.1 | 0.9 ± 0.3 | 1.6 ± 1.6 | 0.5 ± 0.1 | 0.9 ± 0.3 |
| OVX E2 SC | 17.2 ± 2.9a,d,e | 3.0 ± 1.2a,e | 1.5 ± 0.2a,d,e | 4.2 ± 1.5 | 1.3 ± 0.4 | 2.7 ± 1.3 | 6.1 ± 4.4 | 1.3 ± 0.4 | 1.2 ± 0.1c,d,e |
| OVX E2 + P4 | 13.0 ± 6.7a,d,e | 1.3 ± 0.1 | 1.3 ± 0.2a,d,e | 50.9 ± 18.3 | 15.4 ± 5.0a,b,e | 6.7 ± 1.3 | 5.9 ± 0.5 | 7.1 ± 0.5a,b | 9.3 ± 1.0a,a,b |
| OVX P4 SC | 0 | 1.1 ± 0.9 | 0.1 ± 0.0 | 59.9 ± 28.6 | 9.3 ± 3.8 | 18.6 ± 4.3a,b,e | 10.2 ± 2.3 | 6.7 ± 0.9a,b | 9.6 ± 1.1a,b |
| OVX 3α, 5α-THP SC | 0 | 0.2 ± 0.1 | 0.2 ± 0.1 | 2.2 ± 1.1 | 6.0 ± 2.5 | 14.9 ± 6.0a,b | 6.1 ± 0.6 | 9.0 ± 0.9a,b,c,d | 11.9 ± 2.1a,b |
a
Different from vehicle (p ≤ .05).
b
Different from E2 (p ≤ .05).
c
Different from E2 + P (p ≤ .05).
d
Different from P (p ≤ .05).
e
Different from THP (p ≤ .05).