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. Author manuscript; available in PMC: 2013 Dec 5.
Published in final edited form as: Structure. 2012 Oct 11;20(12):2048–2061. doi: 10.1016/j.str.2012.09.003

Figure 3. Slow Dynamics of the Second CARD of RIG-I.

Figure 3

(A) Contributions of chemical exchange Rex to 15N transverse relaxation. Error bars are obtained by the propagation of the spectral noise (versus peak intensity) in all spectra used for the relaxation rate analysis.

(B) These contributions are color-coded onto three orientations of the lowest energy structure of CARD2. The positions of Thr170 and Lys172 as well as residues covering Thr170 are shown in at least one of the orientations.

(C) Amide proton exchange with water derived from the CLEANEX-PM experiment. The color coding corresponds to the following CLEANEX efficiencies: ηCL > 0.02 (red); 0.02 > ηCL > 0.003 (orange); 0.003 > ηCL > 0.001 (yellow). The side-chains of Glu129, Asn166, Thr170, and Lys172 are shown.

See also Figure S2.