Figure 2.

Detailed view of regions of the MHC where there is a difference in gene content or type between gorilla, human reference and chimpanzee. Figure is not to scale. Rectangle = gene; oval = pseudogene; grey fill = type difference (pseudogene versus gene); black fill = gene absent/present in at least one species and not another; black and white striped = not direct orthologue; above line = locus on forward strand (in reference to human chromosomes); below line = locus on reverse strand; stacked = genes overlap or are nested. Gene names are given where available and are only shown for gorilla and chimpanzee when different from human; locus names that appear as numbers with leading zeros are loci without approved nomenclature, with the numbers representing the numerical part of VEGA stable gene IDs (to obtain the full ID, the 11-digit number should be prepended with OTTGORG, OTTPANG or OTTHUMG for gorilla, chimpanzee and human, respectively). An italicised locus name between brackets for a pseudogene indicates the parent gene or gene family of that pseudogene. The loci on the chimpanzee contig in panel B3 are annotated by ENSEMBL (release 70, January 2013), with dotted outlined loci indicating manually determined genes not annotated by ENSEMBL. Section labels A, B and C have been added to allow for easier reference to this figure in the text.