Table 3.

Ordinary least squares regression models for the adjusted odds ratios of factors associated with the medication exposure over time (measured as the proportion of days covered), for each class.

	ACEI/ARBs		B-Blockers		CCBs		≥ 1 Agent
	AOR	P -value	AOR	P -value	AOR	P -value	AOR	P -value
Age, per 10 yrs	1.05	< 0.0001	1.05	< 0.0001	1.10	< 0.0001	1.10	< 0.0001
Male sex	0.98	0.51	1.06	0.035	0.95	0.034	0.93	0.0010
Race/Ethnicity
Caucasian	1.0	−	1.0	−	1.0	−	1.0	−
African- American	0.78	< 0.0001	0.69	< 0.0001	0.85	< 0.0001	0.78	< 0.0001
Hispanic	0.73	< 0.0001	0.56	< 0.0001	0.84	< 0.0001	0.68	< 0.0001
Other	0.97	0.57	0.67	< 0.0001	0.84	0.0005	0.85	0.0004
Inability to ambulate	1.16	0.052	1.13	0.10	1.08	0.29	1.10	0.13
Inability to transfer	0.61	0.0006	0.75	0.038	0.89	0.39	0.61	< 0.0001
Employed	1.14	0.12	1.04	0.61	1.07	0.44	1.00	0.99
BMI category
< 20kg/m2	0.95	0.25	0.99	0.81	0.90	0.024	0.90	0.017
20-24.9kg/m2	1.0	−	1.0	−	1.0	−	1.0	−
25-29.9kg/m2	0.99	0.87	0.97	0.38	0.90	0.0007	0.93	0.0085
30+ kg/m2	0.84	< 0.0001	0.85	< 0.0001	0.79	< 0.0001	0.72	< 0.0001
Smoker	1.00	0.98	0.90	0.032	0.97	0.53	0.94	0.15
Substance abuser	0.97	0.66	0.90	0.15	0.95	0.51	0.92	0.24
Liu Comorbidity Score2	1.02	0.47	1.05	0.12	0.93	0.020	0.99	0.79
Comorbidities
DM	1.28	< 0.0001	0.99	0.66	1.14	< 0.0001	1.23	< 0.0001
CHF	0.99	0.68	1.00	0.94	0.93	0.023	0.98	0.48
CAD	1.00	0.96	1.31	< 0.0001	0.93	0.033	1.11	0.0003
PVD	1.02	0.57	0.91	0.014	0.88	0.0014	0.93	0.057
CVA	1.23	< 0.0001	1.29	< 0.0001	1.25	< 0.0001	1.30	< 0.0001
Hb < 11.0	0.93	0.012	0.90	0.0001	1.00	0.89	0.96	0.13
Self-care dialysis	0.94	0.27	0.99	0.84	0.73	< 0.0001	0.82	< 0.0001

Abbreviations: ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor; β-blocker, β-adrenergic antagonist; CCB, calcium channel blocker; statin, AOR, adjusted odds ratios; BMI, body mass index; HTN, hypertension; DM, diabetes; CHF, congestive heart failure; CAD, coronary artery disease; PVD; peripheral vascular disease; CVA, cerebrovascular accident; Hb, hemoglobin.