Table 1.
Weights, urine volume (UV), and urinary sodium (Na) excretion (UNaV) in mice with no (wild-type (WT)), kidney-specific angiotensinogen (AGT) (K), liver-specific AGT (L), or both transgenes (KL)
| KL | K | L | WT | |
|---|---|---|---|---|
| Normal Na | ||||
| Weight, g | 25.1±0.7 | 23.1±0.4 | 23.8±0.6 | 26.6±0.6 |
| UV, ml/day | 0.7±0.1 | 1.1±0.2 | 0.8±0.1 | 0.8±0.1 |
| UNaV, mmol/day | 79±12 | 115±19 | 98±12 | 95±14 |
| High Na | ||||
| Weight, g | 25.5±0.9 | 24.5±0.4 | 24.7±0.6 | 25.9±0.7 |
| UV, ml/day | 5.1±0.1 | 5.8±0.7 | 5.3±0.7 | 4.4±1.1 |
| UNaV, mmol/day | 2221±429 | 2208±414 | 2791±476 | 1865±681 |
Mice were fed a normal- (0.25%) or high- (3.2%) Na diet. Data are shown on the third day of transitioning to each diet. n = 8 per group.