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Simulated Scenarios A–C
| Scenario | Allele Frequency Differencea | SNP Effect, 
|
Q Effect, βQ | D′ Difference (Heterogeneity) |
|---|---|---|---|---|
| A | 0, 0.4 | None | Log(3.0) | None |
| B | 0, 0.4 | Log(1.2) | None | None |
| C | None | Log(1.2) | Log(3.0) | 0, 1.8 |
Abbreviation: SNP, single-nucleotide polymorphism.
a Allele frequencies at both the disease and the marker loci.
