Table 2.
P Value and Effect Estimate for Selected Markers Across Ethnic Groups and Models in the Ongoing Children's Health Study
Marker | Allele | Local Strataa | Non-Hispanic Whites |
Hispanics |
Combinedb |
|||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No.c | Allele Frequency | Model 3d |
No. | Allele Frequency | Model 3 |
Model 4e |
No. | Allele Frequency | Model 3 |
Model 4 |
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P Value | ![]() |
P Value | ![]() |
P Value | ![]() |
P Value | ![]() |
P Value | |||||||||
rs10119122 | G | L ≈ 0 | 0 | 12 | 0.46 | 0.03 | 12 | 0.46 | 0.04 | |||||||||
L ≈ 1 | 0 | 410 | 0.60 | −0.17 | 410 | 0.60 | −0.17 | |||||||||||
L ≈ 2 | 1,372 | 0.66 | 721 | 0.64 | −0.37 | 2,093 | 0.65 | −0.37 | ||||||||||
All | 1,372 | 0.66 | −0.36 | 2.1 × 10−5 | 1,143 | 0.62 | −0.30 | 1.8 × 10−3 | 4.7 × 10−3 | 2,515 | 0.64 | −0.34 | 4.5 × 10−8 | 1.6 × 10−7 | ||||
rs10519951 | T | L ≈ 0 | 0 | 119 | 0.34 | −1.12 | 119 | 0.34 | −1.17 | |||||||||
L ≈ 1 | 0 | 531 | 0.26 | −0.48 | 531 | 0.26 | −0.49 | |||||||||||
L ≈ 2 | 1,386 | 0.19 | 510 | 0.19 | 0.16 | 1,896 | 0.19 | 0.18 | ||||||||||
All | 1,386 | 0.19 | 0.19 | 7.1 × 10−2 | 1,160 | 0.24 | −0.29 | 5.2 × 10−3 | 1.6 × 10−5 | 2,546 | 0.21 | −0.05 | 5.0 × 10−1 | 8.5 × 10−7 |
a Estimated individual local ancestry. L is rounded up into 3 categorical groups: 0 ; 1 (
> 0.5–1.5); and 2 (
> 1.5).
b Combined non-Hispanic white and Hispanic samples for analysis.
c Sample size within each local stratum.
d Effect estimate of the single-nucleotide polymorphism marginal effect followed by the corresponding P value from model 3: Y ∼ G + Q + L.
e The expected effect estimate of the single-nucleotide polymorphism effect within each local stratum followed by the 2-df test P value from model 4: Y ∼ G + L + GL + Q.