Table 3.

Investigation of Heterogeneity for Single-Nucleotide Polymorphism rs10519951 in Combined Samples from the Ongoing Children's Health Study

	Strata	No.	Allele Frequency	β Coefficient	P Value
All	Combined	2,546	0.21	−0.05	5.0 × 10−1 a
Lb	L ≈ 0 (Asian)	119	0.34	−1.17	8.5 × 10−7
	L ≈ 1	531	0.26	−0.49
	L ≈ 2 (European)	1,896	0.19	0.18
Qb	Q ≈ 0.25 (Asian)	21	0.43	−0.76	2.9 × 10−2 c
	Q ≈ 0.5	480	0.30	−0.35
	Q ≈ 0.75 (European)	2,045	0.19	0.06
Ed	Hispanics	1,160	0.24	−0.29	5.6 × 10−3 c
	Non-Hispanic white	1,386	0.19	0.19

Abbreviation: SNP, single-nucleotide polymorphism.

^a Conventional analysis testing of the SNP main effect only.

^b Estimated individual ancestry is rounded into 3 categorical groups when presenting the number of samples and the allele frequency within each stratum : 0 ; 1 ( > 0.5–1.5); and 2 ( > 1.5). Q: 0.25 (Q ≤ 0.33); 0.5 (Q > 0.33–0.66); and 0.75 (Q > 0.66).

^c Two-df test of the SNP by strata interaction and the SNP marginal effect.

^d Self-reported ethnicity.