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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Exp Dermatol. 2013 Mar;22(3):210–215. doi: 10.1111/exd.12102

Figure 1. Topical Apigenin Improves Epidermal Permeability Barrier Homeostasis in Normal Murine Skin.

Figure 1

Hairless mice were treated topically with 60 µl of 0.1% apigenin in 100% ethanol or ethanol alone twice daily for 9 days. Basal epidermal permeability barrier function, skin surface pH and stratum corneum (SC) hydration were assessed with a MPA5 (CK electronic GmbH, Cologne, Germany) connected to TM 300, pH905 and Corneometer 825. Two readings were taken from each mouse for basal TEWL, hydration, as well as pH. For barrier recovery, TEWL was measured with an electrolytic water analyzer (Meeco, Warrington, PA) at 0, 2 and 4 hours after tape stripping, which results in a 10-fold increase in TEWL, and percent barrier recovery rates were calculated as described earlier (32). Figure 1a is basal TEWL; 1b, SC hydration; 1c, skin surface pH; 1d, barrier recovery. Numbers and significances are indicated in the figures.

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