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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Drug Resist Updat. 2007 Jun 4;10(3):101–108. doi: 10.1016/j.drup.2007.04.001

Fig. 1.

Fig. 1

Structure and functional domain of galectin-3. Galectin-3 consists of three structural domains: (a) a NH2-terminal domain of 12 amino acid that contains a serine phosphorylation site; (b) a repeated collagen-like sequence rich in glycine, proline, and tyrosine; and (c) a COOH-terminal carbohydrate recognition domain (CRD) consisting 140 amino acid residues. The C-terminal domain includes the NWGR motif which is highly conserved in the BH1 domain of the Bcl-2 gene family including Bcl-2, Bcl-xL, and Bax.