Table 1. Risk allele frequencies of the ARMS2 (A69S and del443ins54) and HTRA1 SNPs in different populations.
| Population (N=Cases, Controls) |
rs10490924 (A69S; “T” risk allele) |
del443ins54 (Indel) |
rs11200638 (“A” risk allele) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | P value | OR (95%CI) | Cases | Controls | P value | OR(95%CI) | Cases | Controls | P value | OR (95%CI) | |
| German (760, 549)5 |
0.424 |
0.193 |
2.8 x10-29 |
2.86(2.38-3.44) |
0.424 |
0.193 |
4.1 x10-29 |
2.85(2.37-3.43) |
0.426 |
0.199 |
6.9 x 10-29 |
2.85(2.37-3.42) |
| Caucasian (819, 329)6 |
0.412 |
0.248 |
1.89 x 10-13 |
2.13 (1.74-2.61) |
0.409 |
0.248 |
3.62 x 10-13 |
2.1 (1.71-2.57) |
NA |
NA |
NA |
NA |
| Caucasian (291, 191)7 |
0.36 |
0.23 |
3.31 x 10-5 |
1.86 |
0.36 |
0.23 |
3.46 x 10-5 |
1.85 |
0.36 |
0.24 |
6.41 x 10-5 |
1.8 |
| Utah (705, 650)8 |
0.38 |
0.2 |
8.61 x 10-26 |
NA |
0.39 |
0.2 |
1.9 x 10-26 |
NA |
0.41 |
0.22 |
3.64 x 10-26 |
NA |
| Northern European (442, 434)8 |
0.52 |
0.24 |
4.87 x 10-34 |
NA |
0.53 |
0.25 |
8.35x10-34 |
NA |
0.53 |
0.25 |
2.52 x 10-34 |
NA |
| Italian (159, 286)9 |
NA |
NA |
NA |
NA |
0.51 |
0.24 |
2.7x10-15 |
3.25 (2.36-4.41) |
NA |
NA |
NA |
NA |
| Han Chinese (138, 591)8 |
0.74 |
0.49 |
1.15 x 10-13 |
NA |
0.73 |
0.49 |
6.03 x 10-13 |
NA |
0.77 |
0.52 |
5.10 x 10-13 |
NA |
| Japanese (56, 77)10 |
0.86 |
0.62 |
NA |
NA |
0.875 |
0.66 |
NA |
NA |
NA |
NA |
NA |
NA |
| Australian (624,430)* |
0.445 |
0.202 |
1.97x10-30 |
3.14(2.58-3.86) |
0.446 |
0.199 |
2.78x10-30 |
3.15 (2.58-3.86) |
0.441 |
0.202 |
1.43x10-29 |
3.11(2.54-3.80) |
| South Indian (227, 206)* | 0.63 | 0.36 | 1.85x10-15 | 3.06 (2.31-4.04) | 0.63 | 0.38 | 1.74x10-13 | 2.8 (2.12-3.70) | 0.6 | 0.35 | 9.11x10-11 | 2.76 (2.02-3.77) |
*Data from the current study ; NA = Data not available