Table 2. Genotype counts of the ARMS2 and HTRA1 SNPs in the Indian and Australian cohorts.
| Population | SNP (gene) | Genotypes | Genotype counts |
P value | Odds ratios (95% CI) | |
|---|---|---|---|---|---|---|
| Cases | Controls | |||||
| Australian |
rs10490924 (ARMS2) |
GG |
189 |
271 |
- |
Ref |
| GT |
282 |
138 |
<0.0001 |
2.93 (2.22 - 3.86) |
||
| TT |
145 |
16 |
<0.0001 |
12.99 (7.51 - 22.49) |
||
| Indel -EU427539 (ARMS2) |
Wt/Wt |
190 |
269 |
- |
Ref |
|
| Wt/Indel |
306 |
137 |
<0.0001 |
3.16 (2.41 - 4.16) |
||
| Indel/Indel |
119 |
15 |
<0.0001 |
11.23 (6.36 – 19.82) |
||
|
rs11200638 (HTRA1) |
GG |
194 |
271 |
- |
Ref |
|
| GA |
292 |
138 |
<0.0001 |
2.96 (2.25 – 3.89) |
||
| AA |
130 |
17 |
<0.0001 |
10.68 (6.24 – 18.29) |
||
| Indian |
rs10490924 (ARMS2) |
GG |
39 |
85 |
- |
Ref |
| GT |
84 |
94 |
0.004 |
1.95 (1.21 – 3.15) |
||
| TT |
99 |
26 |
<0.0001 |
8.30 (4.67 – 14.74) |
||
| Indel -EU427539 (ARMS2) |
Wt/Wt |
44 |
84 |
- |
Ref |
|
| Wt/Indel |
79 |
88 |
0.017 |
1.71 (1.16 – 2.75) |
||
| Indel/Indel |
104 |
34 |
<0.0001 |
5.84 (3.43 – 9.94) |
||
| rs11200638 (HTRA1) | GG |
44 |
61 |
- |
Ref |
|
| GA |
70 |
67 |
0.01 |
1.45 (0.87 – 2.42) |
||
| AA | 84 | 17 | <0.0001 | 6.85 (3.58 – 13.12) | ||