Table 3. Major haplotype frequencies at the three loci harboring the ARMS2 (A69S and del443ins54) and HTRA1 variants in the Indian and Australian cohorts.
| HAPLOTYPES (5’-3’) |
SOUTH INDIAN COHORT (n=433) |
AUSTRALIAN COHORT (n=1054) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| rs1094924 (ARMS2) | del443ins54 (ARMS2) | rs11200638 (HTRA1) | % Cases (N=227) | % Controls (N=206) | P values | OR (95%CI) | % Cases (N=624) | % Controls (N=430) | P values | OR (95%CI) |
|
T |
Indel |
A |
57.8 |
30.3 |
5.70x10-16 |
3.16 (2.34-4.19) |
44.1 |
20 |
6.33x10-30 |
3.15 (2.57-3.85) |
| G |
Wt* |
G |
33 |
55.6 |
2.35x10-11 |
0.39 (0.29-0.52) |
55.3 |
79.8 |
1.02x10-30 |
0.31 (0.25-0.38) |
| G |
- |
G |
35.8 |
59.5 |
4.49x10-12 |
0.38 (0.29-0.50) |
55.4 |
79.8 |
1.43x10-30 |
0.31 (0.26-0.38) |
|
T |
- |
A |
58.4 |
30.4 |
1.82x10-16 |
3.20 (2.42-4.25) |
44.1 |
20.2 |
1.55x10-29 |
3.11 (2.55-3.81) |
|
T |
Indel |
- |
59.1 |
31.8 |
1.32x10-15 |
3.09 (2.34-4.10) |
44.4 |
20 |
1.18x10-30 |
3.19 (2.61-3.91) |
| G |
Wt* |
- |
33.5 |
50.4 |
2.54x10-13 |
0.36 (0.27-0.47) |
55.4 |
79.8 |
1.43x10-30 |
0.31 (0.26-0.38) |
|
- |
Indel |
A |
50.8 |
31.8 |
2.41x10-15 |
3.06 (2.31-4.05) |
44.1 |
20 |
6.33x10-30 |
3.15 (2.57-3.86) |
| - | Wt* | G | 35.5 | 59.1 | 5.04x10-12 | 0.38 (0.29-0.50) | 55.3 | 79.8 | 1.02x10-30 | 0.31 (0.26-0.38) |
Combinations of the risk alleles at the three loci are bolded; *Wt = wildtype