Table 2. Categorization of proteins in groups.
| Amyloidogenic proteins | Non-fibrillar amyloid-associated proteins | Structural extracellular matrix proteins | Other extracellular matrix proteins | Structural intracellular proteins | Other intracellular proteins | Membrane-bound proteins |
|---|---|---|---|---|---|---|
| TGFBIp |
Serum amyloid P-component |
Collagen α-1(I) |
Serum albumin |
Keratin 15 |
α-enolase |
Desmoglein-1 |
| Apolipoprotein A-IV |
Clusterin |
Collagen α-2(I) |
S100-A7a |
Keratin 13 |
Histone H2A type 1-A |
|
| Apolipoprotein A-I |
Serine protease HtrA1 |
Keratocan |
Thioredoxina |
Keratin 3 |
ALDH3A1 |
|
| Ig kappa light chain, C and V-III |
Apolipoprotein E |
Collagen α-3(VI) |
Angiopoietin-related protein 7 |
Keratin 12 |
52 kDa Ro protein |
|
| Lysozyme C |
Prostaglandin-H2 D-isomerasea |
Collagen α-1(VI) |
Cytokine-like protein 1 |
Keratin 75 |
Hornerin |
|
| S100-A8 |
Complement component C9 |
Collagen α-2(VI) |
Prolactin-inducible protein |
Keratin 4 |
Desmoplakin |
|
| S100-A9 |
Decorin |
Lumican |
PEDF |
Keratin 71 |
Filaggrin-2 |
|
| Lactotransferrin |
Apolipoprotein D |
Collagen α-2(V) |
Kallikrein-14 |
Keratin 1b |
CAND1 |
|
| |
Cystatin-A |
Collagen α-1(III) |
|
Keratin 23 |
|
|
| |
Vitronectin |
Collagen α-1(V) |
|
Glial fibrillary acidic protein |
|
|
| |
Biglycan |
Collagen α-1(VIII) |
|
|
|
|
| |
Glia-derived nexin |
Prolargin |
|
|
|
|
| |
Complement component C3 |
Collagen α-4(IV) |
|
|
|
|
| |
Thrombospondin-4 |
Collagen α-1(XII) |
|
|
|
|
| 8 (13%) | 14 (22%) | 14 (22%) | 8 (13%) | 10 (16%) | 8 (13%) | 1 (2%) |
The 63 distinct proteins identified in the amyloid deposits from the LCD type 1 variant with the A546D mutation in TGFBI are categorized according to their functional roles and cellular localization reported in current literature. The group with amyloidogenic proteins includes those that cause primary amyloidosis in other diseases. Non-fibrillar amyloid-associated proteins include those that are reported to bind or colocalize with amyloid deposits in other diseases, but are not themselves amyloidogenic in vivo. Structural extracellular matrix proteins include collagens and proteoglycans (leucine-rich repeat proteins), while other extracellular matrix proteins are categorized together. Structural intracellular proteins include intermediate filament proteins such as keratins, while other intracellular proteins are categorized together. Membrane-bound proteins are categorized in one group. The proteins in each group are listed according to relative abundances. The lowest row indicates the number of proteins in each group with the corresponding percentages in brackets. a: the protein can be both extra- and intracellular.