Table 4.
Combined expressions of VEGF-C and CNTN-1 associated with clinicopathologic characteristics (n/%).
| Characteristic | Both high expressiona
(n = 26) |
Both non high expressionb (n = 18) | P value |
|---|---|---|---|
| Age (ys) | 0.761 | ||
| ≧60 | 16/61.5 | 12/66.7 | |
| <60 | 10/38.5 | 6/33.3 | |
| Gender | 0.323 | ||
| Male | 20/76.9 | 11/61.1 | |
| Female | 6/23.1 | 7/38.9 | |
| Tumor size | 0.234 | ||
| ≧5 cm | 17/65.4 | 8/47.1 | |
| <5 cm | 9/34.6 | 9/52.9 | |
| Tumor location | 0.292 | ||
| Upper | 10/38.4 | 3/16.7 | |
| Middle | 8/30.8 | 7/38.9 | |
| Lower | 8/30.8 | 8/44.4 | |
| Lauren's classification | 0.395 | ||
| Intestinal | 14/53.8 | 12/66.7 | |
| Diffuse | 12/46.2 | 6/33.3 | |
| TNM stage | 0.023 | ||
| I + II | 5/19.2 | 10/55.6 | |
| III + IV | 21/80.8 | 8/44.4 | |
| Vascular invasion | 0.325 | ||
| (+) | 15/57.7 | 13/72.2 | |
| (−) | 11/42.3 | 5/27.8 | |
| Serosa invasion | 0.014 | ||
| (+) | 9/34.6 | 13/72.2 | |
| (−) | 17/63.4 | 5/27.8 | |
| Lymphatic invasion | 0.005 | ||
| (+) | 25/96.2 | 11/61.1 | |
| (−) | 1/3.8 | 7/38.9 | |
| Lymph node metastasis | 0.013 | ||
| (+) | 25/96.2 | 12/66.7 | |
| (−) | 1/3.8 | 6/33.3 | |
| Lymph node metastatic ratio | 0.395 | ||
| ≧20% | 12/46.2 | 6/33.3 | |
| <20% | 14/53.8 | 12/66.7 | |
| Average survival (mean ± SD) (months) | 16.8 ± 3.8 | 23.2 ± 5.0 | 0.032 |
Note: “a”: indicates that expression of both VEGF-C and CNTN-1 in tumor cells is high. “b”: indicates samples with combined expressions of VEGF-C and CNTN-1 except those of both high expressions.