Table 1.

Neurotoxicities reported to be associated with biologically targeted agents

Class	Drug	Neurotoxicity
EGFR inhibitors	Erlotinib	Worsening of peripheral neuropathy from other agents
	Gefitinib	Intratumoral hemorrhage
PDGF inhibitors	Imatinib	Intratumoral hemorrhage, myalgias, muscle cramping, possible growth impairment
VEGF inhibitors	Bevacizumab	Bleeding, cerebrovascular events, PRES, radiation necrosis
Farnesyltransferase inhibitors	Tipifarnib	Peripheral neuropathy, headache, dizziness (all rare in children)
Raf inhibitors	Sunitinib and sorefenib	PRES, cerebrovascular events
mTOR inhibitors	Sirolimus	PRES, cerebrovascular events
Antiangiogenetic	Thalidomide	Peripheral neuropathy
Histone deactylase inhibitors	Suberoylanilide hydroxamic acid	Fatigue
	Valproic acid (Depakote)	Somnolence
Proteasome inhibitors	Bortezomib	Peripheral neuropathy

Abbreviations:

EGFR = Epidermal growth factor receptor

mTOR = Mammalian target of rapamycin

PDGF = Platelet-derived growth factor

PRES = Posterior reversible encephalopathy syndrome

VEGF = Vascular endothelial growth factor