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. 2013 Mar 5;54(3):1636–1649. doi: 10.1167/iovs.12-11107

Figure 8.

Figure 8

The schematics of MRP4 regulated efflux of cAMP and cGMP and its inhibition by MK571 leads to increased levels of intracellular cAMP and cGMP and activation of PKA and PKG. Bold arrows indicate a preferential activation of PKG in HTM cells treated with MK571under the conditions described in this study.