Figure 5. .

EMP2 increases HUVEC tube formation. Vessel tube number was measured following incubation of HUVEC cells in conditioned media from ARPE-19/EMP2, ARPE-19, and ARPE-19 cells treated with control siRNA or EMP2 siRNA was counted and an average was calculated from several fields. Increased expression of EMP2 significantly increased vessel tube number (*P = 0.03) as compared with ARPE-19 cells. Decreased EMP2 expression by EMP2 siRNA significantly decreased vessel tube number (**P = 0.003) as compared with control siRNA treated cells.