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. Author manuscript; available in PMC: 2013 Sep 5.
Published in final edited form as: Cell Metab. 2013 Mar 5;17(3):423–435. doi: 10.1016/j.cmet.2013.01.016

Figure 1. TLE3 modulates the differentiation program of brown preadipocytes.

Figure 1

A. Time course of TLE3 protein expression during the differentiation of immortalized primary brown preadipocytes determined by immunoblotting. B. Induction of aP2 precedes induction of the brown adipocyte marker Cidea in primary brown adipocytes as determined by realtime PCR. C. TLE3 protein expression in mouse tissues determined by immunoblotting. D. TLE3 protein expression in brown preadipocytes transduced with control or TLE3-expressing retroviral vectors. E. Oil red-O staining (top) and bodipy staining (bottom) of control and TLE3-expressing brown preadipocytes 5 days after induction of differentiation. F. Expression of WAT- and BAT-selective target genes in control and TLE3-expressing brown preadipocytes. Similar results were obtained as in E and F with multiple independent control and TLE3-expressing cell pools.