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. 2013 Apr 15;8(4):e59964. doi: 10.1371/journal.pone.0059964

Figure 5. Knockout (KO) and control (CT) mice sensitize to AMPH.

Figure 5

Mice were treated in the same paradigm as outlined in Fig. 1A. Distance traveled during a 90-min test after AMPH or SAL injection. Control SAL (n = 6); Control AMPH (n = 8 ); KO SAL (n = 8); KO AMPH (n = 8). Two-way repeated measures ANOVA: interaction; F(6,84)  = 2.62, *P = 0.022; day effect; F(5,130) = 20.46, ***P<0.01; treatment effect, F(3,26)  = 14.41, ***P<0.01. Bonferroni's post test shows a significant difference between KO and CT mice on day three, noted on the graph with *. Data represent means ± SEM.