Skip to main content
. 2013 Apr 15;8(4):e59964. doi: 10.1371/journal.pone.0059964

Figure 6. Sensitized knockout mice do not show increased locomotor learning.

Figure 6

Rotarod performance by control AMPH-sensitized (n = 6) and SAL-treated mice (n = 5) was the same and both groups demonstrated motor learning over time. Rotarod performance by knockout AMPH-sensitized (n = 8) and SAL-treated (n = 8) mice were equivalent; knockout AMPH-treated mice showed no improvement with training. Two-way, repeated-measures ANOVA: interaction F(24, 176)  = 3.13; P<0.01; treatment F(3,22)  = 29.21; P<0.01; day effect F(24,176)  = 3.133; P<0.01. Tukey's multiple comparisons test shows a significant difference between the performance of control (CT) and KO mice, but no significant difference between the performance of SAL vs. AMPH treatment in either the KO or CT groups. Data represent means ± SEM.