Table 2.
Estimated best combinations of SNPs on the occurrence of breast cancer in the high risk group
| Combined SNP number (specific SNPs) | SNP Genotypes | Control number / Case number | CC | SN | SP | Average | Odds Ratio (CI) | p-value |
|---|---|---|---|---|---|---|---|---|
| Two SNPs |
Other |
330/209 |
|
|
|
|
|
|
| SNPs (4, 7) |
2-3 |
4/11 |
0.615 |
0.050 |
0.988 |
0.551 |
4.342 (1.259-16.934) |
0.013 |
| (Diff. = 7) | ||||||||
| Three SNPs |
Other |
314/191 |
|
|
|
|
|
|
| SNPs (3, 5, 6) |
2-1-1 |
20/29 |
0.619 |
0.132 |
0.940 |
0.564 |
2.384 (1.263-4.518) |
0.005 |
| (Diff. = 9) | ||||||||
| Four SNPs |
Other |
325/203 |
|
|
|
|
|
|
| SNPs (3, 4, 5, 6) |
2-1-1-1 |
9/17 |
0.617 |
0.077 |
0.973 |
0.556 |
3.024 (1.246-7.491) |
0.008 |
| (Diff. = 8) | ||||||||
| Five SNPs |
Other |
329/210 |
|
|
|
|
|
|
| SNPs (1, 3, 4, 5, 6) |
1-2-1-1-1 |
5/10 |
0.612 |
0.045 |
0.985 |
0.547 |
3.133 (0.969-10.680) |
0.031 |
| (Diff. = 5) | ||||||||
| Six SNPs |
Other |
332/214 |
|
|
|
|
|
|
| SNPs (1, 2, 3, 5, 6, 7) |
1-2-2-1-1-2 |
0/4 |
0.610 |
0.018 |
1.000 |
N.E |
||
| (Diff. = 4) |
||||||||
| Seven SNPs |
Other |
333/216 |
|
|
|
|
|
|
| SNPs (1, 2, 3, 4, 5, 6, 7) | 2-2-2-1-1-1-1 | 1/4 |
0.608 | 0.014 | 0.997 | 0.540 | 6.167 (0.648-145.871) | 0.084 |
| (Diff. = 3) |
NOTE - Other: The reference group, indicating the union of all other possible two to seven SNP combinations; N.E: Not estimable; CC: Correct; SN: Sensitivity; SP: Specificity.