Table 3.
Estimated best combinations of SNPs on the occurrence of breast cancer in the low risk group
| Combined SNP number (specific SNPs) | SNP Genotypes | Control number / Case number | CC | SN | SP | Average | Odds Ratio (CI) | p-value |
|---|---|---|---|---|---|---|---|---|
| Two SNPs |
Other |
197/151 |
|
|
|
|
|
|
| SNPs (3, 4) |
1-1 |
137/69 |
0.480 |
0.314 |
0.600 |
0.465 |
0.657 (0.452-0.955) |
0.025 |
| (Diff. = 68) | ||||||||
| Three SNPs |
Other |
260/189 |
|
|
|
|
|
|
| SNPs (1, 3, 5) |
2-1-1 |
74/31 |
0.525 |
0.141 |
0.778 |
0.481 |
0.576 (0.355-0.934) |
0.020 |
| (Diff. = 43) | ||||||||
| Four SNPs |
Other |
294/207 |
|
|
|
|
|
|
| SNPs (1, 2, 3, 4) |
2-2-1-1 |
40/13 |
0.554 |
0.059 |
0.880 |
0.498 |
0.462 (0.228-0.919) |
0.018 |
| (Diff. = 27) | ||||||||
| Five SNPs |
Other |
310/215 |
|
|
|
|
|
|
| SNPs (1, 2, 3, 4, 5) |
2-2-1-1-1 |
24/5 |
0.569 |
0.023 |
0.928 |
0.507 |
0.300 (0.099-0.846) |
0.011 |
| (Diff. = 19) | ||||||||
| Six SNPs |
Other |
323/218 |
|
|
|
|
|
|
| SNPs (1, 2, 3, 4, 5, 6) |
2-2-1-1-1-2 |
11/2 |
0.587 |
0.009 |
0.967 |
0.521 |
0.269 (0.041-1.301) |
0.070 |
| (Diff. = 9) | ||||||||
| Seven SNPs |
Other |
325/219 |
|
|
|
|
|
|
| SNPs (1, 2, 3, 4, 5, 6, 7) | 2-2-1-1-1-2-1 | 9/1 |
0.588 | 0.005 | 0.973 | 0.522 | 0.165 (0.008-1.277) | 0.098 |
| (Diff. = 8) |
NOTE - Other: The reference group, indicating the union of all other possible two to seven SNP combinations; N.E: Not estimable; CC: Correct; SN: Sensitivity; SP: Specificity.