Table 1.
Proteins that show decreased expression in T21 amniocytes (n = 29)
| Gene name | Protein name | Ratio (H/L)1 |
|---|---|---|
| AKAP12 |
A-kinase anchor protein 12 |
0.41 |
| APOA1 |
Apolipoprotein A-I |
0.07 |
| APOC3 |
Apolipoprotein C-III variant 1 |
0.12 |
| ARHGEF2 |
Rho guanine nucleotide exchange factor 2 |
0.52 |
| CNBP |
cDNA FLJ77718 |
0.42 |
| CTRB1 |
cDNA FLJ77335, highly similar to Homo sapiens chymotrypsinogen B1 (CTRB1), mRNA |
0.12 |
| ERC1 |
ELKS/RAB6-interacting/CAST family member 1 |
0.63 |
| FBLIM1 |
Filamin-binding LIM protein 1 |
0.62 |
| FHL3 |
Four and a half LIM domains protein 3 |
0.59 |
| HMGA2 |
HMGA2e |
0.52 |
| HPX |
Hemopexin |
0.22 |
| ICAM1 |
Intercellular adhesion molecule 1 |
0.62 |
| IGF2R |
Cation-independent mannose-6-phosphate receptor |
0.65 |
| LTF |
Lactotransferrin |
0.05 |
| MARCKSL1 |
MARCKS-related protein |
0.58 |
| MCAM |
Cell surface glycoprotein MUC18 |
0.45 |
| NES |
NES protein |
0.18 |
| NUBP1 |
Nucleotide-binding protein 1 |
0.30 |
| PCK2 |
cDNA FLJ50710, highly similar to Phosphoenolpyruvate carboxykinase (GTP), mitochondrial (EC 4.1.1.32) |
0.57 |
| PGPEP1 |
Pyroglutamyl-peptidase 1 |
0.65 |
| POSTN |
Periostin |
0.25 |
| PPIF |
Peptidyl-prolyl cis-trans isomerase, mitochondrial |
0.20 |
| PZP |
Pregnancy zone protein |
0.11 |
| SDCBP |
Syndecan binding protein (Syntenin) |
0.46 |
| SLC2A1 |
Solute carrier family 2, facilitated glucose transporter member 1 |
0.52 |
| SOLO |
Protein SOLO |
0.39 |
| TAF15 |
TATA-binding protein-associated factor 2N |
0.39 |
| TNS1 |
Tensin-1 |
0.57 |
| TRIP6 | Thyroid receptor-interacting protein 6 | 0.64 |
1. Heavy/light ratio with SILAC method, calculated as the average of three experimental pairs when available. Only proteins which showed decreased ratio for different peptides, as well as consistency in the pattern of expression of experimental pairs were selected.