Table 3.
Comparison of T21/CN ratios between SILAC and SRM analysis from a total of 8 experimental pairs (3 pairs for SILAC and 5 pairs for SRM experiments)
|
Gene |
T21/CN ratios according to gestational age (weeks) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Name | 15.1 | 15.5 | 15.9 | 16.3 | 16.4 | 17.3 | 18.6 | 21.5 |
| NES |
0.79* |
0.19 |
0.34* |
0.31* |
0.17 |
1.26 |
0.67* |
N/A |
| SOD1 | 1.54* | 1.98 | 1.85* | 1.46* | 1.74 | 1.75* | 1.16 | 2.02 |
T21, Trisomy 21; CN, chromosomally normal; N/A: Not available.
Bolded: Ratios (T21/CN) from SRM analysis.
Italicized: Ratios (T21/CN) from SILAC analysis.
*Statistically significant ratios at p < 0.001, according to Student’s t-test when the six replicates where compared.
Only the results of two proteins with highly significant fold-change in four out of five sample pairs (SRM) are displayed.