Table 5.
Enriched GO categories for common impairment genes
| Genes down-regulated with impairment in both AD and HIV | ||||||
|---|---|---|---|---|---|---|
| Gene Category |
List Hits |
List Total |
Pop Hits |
Pop Total |
EASE score |
Bonferroni |
| Cytoplasm |
175 |
259 |
2277 |
4968 |
5.62E-13 |
1.40E-09 |
| Energy pathways |
26 |
259 |
128 |
5016 |
4.16E-09 |
1.04E-05 |
| Mitochondrion |
48 |
259 |
396 |
4968 |
3.27E-08 |
8.15E-05 |
| Tricarboxylic acid cycle |
10 |
259 |
20 |
5016 |
2.24E-07 |
5.58E-04 |
| Transit peptide |
28 |
217 |
184 |
4007 |
1.14E-06 |
2.85E-03 |
| Synaptic vesicle |
10 |
259 |
30 |
4968 |
1.31E-05 |
3.26E-02 |
|
Genes up-regulated with impairment in both AD and HIV |
||||||
| Cell differentiation |
10 |
131 |
90 |
5016 |
4.79E-13 |
1.40E-09 |
| Activator |
11 |
105 |
131 |
4007 |
1.89E-03 |
1.00E + 00 |
| Repeat |
42 |
105 |
1051 |
4007 |
1.98E-03 |
1.00E + 00 |
| Cell communication |
50 |
131 |
1363 |
5016 |
5.20E-03 |
1.00E + 00 |
| Regulation of transcription |
32 |
131 |
762 |
5016 |
5.70E-03 |
1.00E + 00 |
| Phosphorylation | 26 | 105 | 582 | 4007 | 6.18E-03 | 1.00E + 00 |
All genes in this list were correlated with MMSE in Blalock et al. [25] (R > 0.25), as well as with GCR in the current analysis of HIV brains (both FC and BG, R > 0.25).