Table 7.
Common genes correlated with neurocognitive impairment in AD and HIV
|
Gene probe |
Function* |
Scaled intramodule connectivity kIN/max (kIN) |
||
|---|---|---|---|---|
| Up with impairment | AD hippocampus | HIV frontal cortex | HIV basal ganglia | |
| CTDSP2 |
Cancer |
1.0 |
1.0 |
1.0 |
| SASH1 |
Cancer |
0.84 |
0.95 |
-- |
| FBXW12 |
|
0.86 |
-- |
0.79 |
| HIPK2 |
Cancer |
0.77 |
0.74 |
0.72 |
| CASC3 |
Cancer |
0.74 |
-- |
0.74 |
| CEP350 |
|
0.72 |
0.90 |
-- |
| PGF |
Cancer |
0.71 |
-- |
0.73 |
| HS1BP3 |
Neurologic |
0.71 |
-- |
0.72 |
|
Down with Impairment |
|
AD hippocampus |
HIV frontal cortex |
HIV basal ganglia |
| SCG5 |
Neurologic |
0.96 |
-- |
0.85 |
| VDAC1 |
Mitochondria |
0.95 |
0.99 |
0.92 |
| KIAA1279 |
Neurologic |
0.93 |
-- |
0.70 |
| PFDN4 |
|
0.92 |
0.84 |
-- |
| MDH1 |
Mitochondria |
0.90 |
0.84 |
1.0 |
| ATP5G3 |
Mitochondria |
0.90 |
0.95 |
0.99 |
| DYNC1I1 |
Neurologic |
0.89 |
0.83 |
0.83 |
| PCMT1 |
Neurologic |
0.86 |
0.98 |
0.90 |
| TOMM20 |
Mitochondria |
0.86 |
-- |
0.92 |
| KLC1 |
Microtubule |
0.86 |
0.96 |
-- |
| NDFIP1 |
|
0.86 |
0.73 |
0.84 |
| KIFAP3 |
Neurologic |
0.85 |
0.87 |
-- |
| THYN1 |
|
0.85 |
0.74 |
0.78 |
| GOT1 |
Mitochondria |
0.84 |
0.83 |
0.84 |
| TBC1D9 |
|
0.84 |
0.75 |
0.90 |
| UCHL1 |
Neurologic |
0.84 |
0.84 |
0.92 |
| ACTR10 |
|
0.84 |
0.88 |
0.85 |
| CISD1 |
Mitochondria |
0.83 |
0.83 |
0.75 |
| SMAP1 |
|
0.82 |
0.76 |
-- |
| C14orf2 |
|
0.82 |
0.77 |
0.76 |
| PEX11B |
|
0.81 |
0.93 |
-- |
| SLC4A1AP |
|
0.81 |
0.71 |
-- |
| COPS4 |
|
0.81 |
0.87 |
0.79 |
| ITFG1 |
|
0.80 |
0.84 |
0.76 |
| GLOD4 |
|
0.79 |
-- |
0.83 |
| DNAJA2 |
Mitochondria |
0.78 |
0.74 |
0.73 |
| SUCLA2 |
Mitochondria |
0.76 |
0.87 |
0.84 |
| NDUFB6 |
|
0.76 |
-- |
0.78 |
| EBNA1BP2 |
|
0.76 |
-- |
0.72 |
| TUBA4A |
|
0.75 |
-- |
-- |
| HINT1 |
Cancer |
0.75 |
0.86 |
0.80 |
| ATP6V1E1 |
Mitochondria |
0.74 |
-- |
0.75 |
| GUCY1B3 |
|
0.72 |
0.83 |
0.91 |
| ATP5H |
Neurologic |
0.72 |
0.73 |
-- |
| GPI |
|
0.70 |
0.75 |
-- |
| BEX1 | Neurologic | 0.70 | -- | 0.72 |
*Gene function was determined by reviewing information within the Online Mendelian Inheritance in Man database http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim.