Figure 4.

The original model by Neumann et al. and results of the model reduction. A. The original model decomposed into modules according to three steps of the CD95 signaling pathways: activation of caspase-8, pro-apoptotic pathway resulting in caspase-3 activation and anti-apoptotic pathway regulated by NF-κB. The species retained during the model reduction are colored; reactions are represented by solid lines. B. The modular view of the model. Activation of caspase-8 and p43-FLIP (product of cFLIPL cleavage) occurs at the DISC complex and triggers simultaneous processes of cell death and survival.