Figure 8.

The composite model of the CD95- and NF-κB-signaling. A. The model integrating pro- and anti-apoptotic machinery described by the models by Neumann et al. and Bentele et al. Reactions with the “nr” titles were taken from the first model, while the “br” titles indicate reactions from the second one. The “*” symbol marks reactions defined in the reduced models. The subscript “m” means that reaction was modified for the models composition. B. The modular view of the model. Activation of caspase-8 triggered by CD95 leads to NF-κB activation and cell survival, on the one hand, and PARP cleavage resulted in the cell death, on the other hand.