Table 1.

Stability of busulfan (0.55 mg/mL) under different storage conditions. Busulfan content was monitored over 15 h (one analysis every 3 h)

Container	Temperature (°C)	Initial concentrationa (mg/mL)	Percentage of initial concentration remaininga
			3 h	6 h	9 h	12 h	15 h
PP syringes	4	0.240 ± 0.2	101.5 ± 1.3	100.7 ± 1.3	100.9 ± 1.2	100.3 ± 1.1	100.4 ± 1.0
	13	0.238 ± 0.7	100.5 ± 3.2	99.1 ± 2.8	97.4 ± 4.1	94.3 ± 3.4	92.5 ± 4.2
	20	0.236 ± 0.9	100.2 ± 3.7	97.1 ± 1.6	95.8 ± 1.5	93.8 ± 1.9	91.7 ± 1.7
PVC bags	4	0.279 ± 0.5	97.9 ± 2.9	90.9 ± 6.2	49.7 ± 8.5	40.9 ± 4.5	14.9 ± 2.5
	13	0.230 ± 0.4	97.1 ± 2.1	97.3 ± 2.6	80.8 ± 4.7	65.0 ± 5.8	39.1 ± 5.9
	20	0.283 ± 1.4	94.6 ± 5.1	97.0 ± 4.1	91.9 ± 4.3	88.5 ± 6.6	82.4 ± 12.1
Glass bottles	4	0.290 ± 2.7	79.9 ± 6.7	57.3 ± 18.3	45.5 ± 12.3	35.4 ± 19.1	39.1 ± 16.2
	13	0.247 ± 0.6	97.6 ± 4.3	87.6 ± 1.3	92.1 ± 14.2	81.8 ± 17.6	70.6 ± 26.2
	20	0.261 ± 0.7	85.4 ± 7.4	75.2 ± 9.1	66.7 ± 11.9	59.0 ± 11.7	56.0 ± 10.3

^aValues presented as mean ± standard deviation (n = 6)

PP polypropylene, PVC polyvinyl chloride