Table 3.
Expression and binding antibody clones.
| Ly49 | Expression | Antibodies |
|---|---|---|
| Ly49A | NK, NK T (To et al., 2009), NK1.1+ γδ (Hara et al., 2001), subset NK1.1−/DX5−/CD3+ T (Ortaldo et al., 1998); subset of CD8+ Tregs (Kim et al., 2011) | 12A8, A1 (B6), JR9-318 (B6, Balb/c); YE1/32, YE1/48 (Held et al., 1995) |
| Ly49B | CD11b+/F4/80+/Gr1+ myeloid cells, activated NK, iNKT cell line, granulocytes (neutrophils, eosinophils, mast cells) macrophages, independent of Ly49Q (Held et al., 1995; Gays et al., 2006) | 1A1 (Gays et al., 2006) |
| Ly49C | NK, NK T (To et al., 2009), NK1.1+ γδ (Hara et al., 2001), subset NK1.1−/DX5−/CD3+ T (Ortaldo et al., 1998); subset of CD8+ Tregs (Kim et al., 2011) | Ly49C/I SW5E6; Ly49C/F/I/HB6 14B11 |
| Ly49D | NK only, not on DX5− T (Ortaldo et al., 1998) | 4E5; 12A1 |
| Ly49E | Fetal NK, thymic NKT (Aust et al., 2011), γδ T (Van Beneden et al., 2001) | Ly49E/C binds 4D12 (Van Beneden et al., 2002) CM4 (Ly49E/F) (Aust et al., 2011) |
| Ly49F | Expression unclear (Corral et al., 1999); CD8+ Tregs (Kim et al., 2011) | Ly49C/I/HB6 14B11 |
| Ly49G | NK, NK T (To et al., 2009), NK1.1+ γδ (Hara et al., 2001), subset NK1.1−/DX5−/CD3+ T (Ortaldo et al., 1998); subset of CD8+ Tregs (Kim et al., 2011) | 4D11; Ly49G2B6 Cwy-3; Ly49G129/Balb AT8 |
| Ly49H | NK, others unknown | 14B11 which recognizes Ly49C/F/I (Corral et al., 1999) |
| Ly49I | NK, NK T (To et al., 2009), NK1.1+ γδ (Hara et al., 2001) | 3D10; Ly49C/I SW5E6; Ly49C/I/F/HB6 14B11 |
| Ly49Q | Myeloid cells CD11b+/B220+/CD4+, and/or CD8+ (Toyama-Sorimachi et al., 2004); pDCs (Kamogawa-Schifter et al., 2005); and Osteoclasts (Hayashi et al., 2010) | |
| Ly49O | NK, others unknown | YE1/32, YE1/48 (Held et al., 1995) |
| Ly49V | NK | 4E 5 |