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. Author manuscript; available in PMC: 2013 Apr 16.
Published in final edited form as: Sci Transl Med. 2012 Jan 4;4(115):115ra1. doi: 10.1126/scitranslmed.3003155

Figure 3. Specificity of T cell responses primed after vaccination with Ad6-NSmut or ChAd3-NSmut.

Figure 3

(A) Immunodominance of primed responses: Data are taken from the IFNγ ELISpot responses from high dose groups (3, 9; Ad6-NSmut 2.5 ×1010 vp and 7, 10; ChAd3 2.5 ×1010vp) at peak magnitude after prime. The magnitude of the HCV-specific T cell response to individual peptide pools (F-M), and the corresponding NS protein below is shown (Bars=mean +/− SEM, ▯=statistical significance p=0.0001).

(B) Individual volunteer data showing targeted pools after priming with Ad6-NSmut 2.5 ×1010 vp group 3 (upper panel) and ChAd3-NSmut 2.5 ×1010vp group 7 (lower panel) is shown.