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. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: J Med Chem. 2013 Mar 7;56(6):2270–2282. doi: 10.1021/jm301643a

Scheme 1a.

Scheme 1a

aReagents and conditions: (i) ArNHNH2 HCl, MeOH, reflux; (ii) 10% acq NaOH, MeOH, reflux; (iii) a) SOCl2, reflux; b) ArNH2 or ArOH, Et3N, dry DMF, 40 °C; (iv) H2, Raney-Ni, DMF, rt, atm pressure.