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. Author manuscript; available in PMC: 2013 Apr 16.
Published in final edited form as: Cell Metab. 2011 Dec 7;14(6):747–757. doi: 10.1016/j.cmet.2011.11.006

Figure 4. TGR5 inhibits oxidized LDL uptake.

Figure 4

(A and B) Sr-a (A) and Cd36 (B) mRNA expression in macrophages isolated from Tgr5+/+ and Tgr5−/− mice in response to INT-777 treatment (black bars) or control-treated (white bars; n=3). (C) Fluorescence of DiI-labeled oxidized LDL extracted from macrophages isolated from Tgr5+/+ and Tgr5−/− mice in response to INT-777 (black bars) or control conditions (white bars; n=3) (D-I) Confocal fluorescent images of macrophages from Tgr5+/+ (D, E, F) and Tgr5−/− (G, H, I) mice treated with DiI-labeled oxidized LDL (E, F, H, I) in combination with INT-777 treatment (F, I). Results represent the mean ± SEM. * Statistically significant, P<0.05.