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. Author manuscript; available in PMC: 2013 Apr 16.
Published in final edited form as: Cell Metab. 2011 Dec 7;14(6):747–757. doi: 10.1016/j.cmet.2011.11.006

Figure 5. TGR5 activation inhibits atherosclerosis.

Figure 5

(A) Plaque size in the aortic root of Ldlr−/−Tgr5+/+ (white symbols) and Ldlr−/−Tgr5−/− animals (black symbols) treated with INT-777 (squares) or control-treated (circles) (n=8-9). (B-E) Oil-red-O staining of atherosclerotic lesions in the aortic root of Ldlr−/−Tgr5+/+ (B and C) or Ldlr−/−Tgr5−/− animals (D and E) treated with INT-777 (C and E) or control-treated (B and D). (F and G) Plasma cholesterol (F) and triglycerides (G) of Ldlr−/−Tgr5+/+ and Ldlr−/−Tgr5−/− animals treated with INT-777 (black bars) or control-treated (white bars; n=8-9). (H-I) mRNA levels of (H) Tnfα and (I) Il-1β in aortic root lesions captured by laser capture micro-dissection of Ldlr−/−Tgr5+/+ and Ldlr−/−Tgr5−/− animals treated with INT-777 (black bars) or control-treated (white bars; n=3). Results represent the mean ± SEM. * Statistically significant, P<0.05.